Researchers found cutting the food intake of just about any organism by up to 30-40 percent extended its life by as much as 60 percent.
Calorie restriction reduces insulin levels and triggers the production of sirtuins, which are produced as part of an intricate stress response that kicks an organism into survival mode (which beefs up DNA repair and prevents cells from dying).
13 minute video: http://www.pbs.org/wgbh/nova/sciencenow/3401/01.html.
You Don't Need a Drug to Make it to 100
Researchers have discovered that a molecule called nicotinamide, a component of vitamin B3 (niacin), binds to a sirtuin protein and prevents it from unleashing its renowned anti-aging effects.
A drug that prevents the niacin-sirtuin interaction could therefore help counteract age-related disorders, including obesity and type 2 diabetes.
Two Massachusetts-based companies are already working to develop drugs that affect sirtuin activity. Elixir Pharmaceuticals has filed more than 20 patents or applications related to a sirtuin class of compounds: http://www.mercola.com/2007/mar/3/you-dont-need-a-drug-to-make-it-to-100.htm.